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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Comparison of the Effects of Oral Arnebia Euchroma and Oral ANGIPARS on Wounds in Diabetic Rats

Author: ALI ISHARIF, ELHAM SHAFIEI, MORTEZA HOSSEINZADEH
Abstract: Diabetic foot ulcer is one of the most common causes of amputation and imposes high social costs. The present study was conducted to evaluate the effect of oral arnebia euchroma extract on wounds in diabetic rats and was compared with oral and topical forms of ANGIPARS.Thirty diabetic male Wistar rats were categorized into different groups with similar wounds, and were treated with oral and topical forms of arnebia euchroma extract and ANGIPARS ointment and capsules, and were compared with each other and the control group. The clinical and statistical results indicate the superior effect of oral and topical forms of arnebia euchroma extract in comparison with oral and topical forms of ANGIPARS.The epithelial thickness(F (4.25) = 4189.10, p<0.01) and complete healing time(F (4.25) = 18.01, p<0.01), were respectively calculated. It is recommended that a human study be conducted to determine the level of blood glucose and its effect on TNFa and myeloperoxidase as the factors affecting tissue repair.
Keyword: Arnebia Euchroma; ANGIPARS; Diabetic Foot
DOI: https://doi.org/10.31838/ijpr/2019.11.03.015
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