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Diuretic effect of Adiantumcapillus and its chemical constituents in hypertensive rats
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| Author:
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ROSHNA AZIZ, KAWADIZAYE
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| Abstract:
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The present study aims to evaluate the diuretic effect of Adiantumcapillusand some of its chemical constituents in
hypertensive rats. Forty-eight rats were split into eight groups. Twelve normal rats were included in the first group;
six served as negative controls and six were administered Adiantumcapillus. The second group was comprised of 36
hypertensive rats sectioned into six subgroupswith six rats. The first subgroup functioned as a positive control. The
second subgroup was administered an aqueous extract of Adiantumcapillus, while the third subgroup received
chlorthalidone. The remaining three groups were administered flavonoids, alkaloids and phenolicsextracted from
Adiantumcapillus. Urine output, blood pressure and pulse rate were monitored. The subjects’ glomerular filtration
rate, urea and creatinine levels, and serum electrolyte concentration and excretion rates were measured. The results
were then compared with results of the standard antihypertensive drug chlorthalidone. It was concluded that
Adiantumcapillus administration increased urine flow and the sodium excretion rate and lowered systolic blood
pressure in hypertensive rats. Other constituents of Adiantumcapillus, apart from flavonoids, alkaloids and phenolics,
could be responsible for these observations.
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| Keyword:
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Adiantumcapillus,Flavonoids, alkaloids, phenolics, Diuretic,Hypertensive rats.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.03.014
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| Download:
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