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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Quality Control Parameters of Disintegration and Weight Variation Studies of Market Samples of Selected Siddha Tablets - A Comparative Study

Author: SHREE MS,, SATHIYARAJESWARAN P, KIRUBAKARAN.N, VINOD NP, GUNASEKARAN.R, KARTHICK RAJA.S
Abstract: The Pharmaceutical industry in Siddha medicine meets a challenge to deliver the quality of medicine at each dose level due to the handmade preparations & processes as mentioned in Siddha system of medicines. The present work aims to survey, the selected tablets available in the market and study important quality parameters like, Disintegration test (DT) & Weight Variation (WV) as per the Indian pharmacopeia. The major Siddha market samples (Brahmananda Bairavam, Swasa Kudori Mathirai, Santha Chandrodayam, Vasantha Kusumakaram, Murukkanvidai, Vishnu chakram, Kungumapoo, Neerkovai, Balasanjeevi, Lavankathi) purchased from Different manufactures (B1, B2, B3, B4) and the DT (37±2°C, 45±2°C) & WV performed. The results indicate intake of Tablets with slight warm water will improve the tablet disintegration of Brahmananda Bairavam, Swasa Kudori Mathirai, Santha Chandrodayam, Vasantha Kusumakaram, Kungumapoo, Neerkovai, Balasanjeevi, Lavankathi. But there is no impact on Vishnu chakram & Murukkanvidai by using slight warm water. The results of DT (37.5°C) of Balasanjeevi (B4), Santha Chandrodayam (B4), Swasa Kudori Mathirai (B1, B2, B4), (B4) complies (within 15 minutes). The results of DT (45°C) of Balasanjeevi (B2, B4), Brahmananda Bairavam(B4), Santha Chandrodayam (B2, B4), Swasa Kudori Mathirai (B1, B2, B4), Vasantha Kusumakaram (B4), Vishnu chakram (B4), Kungumapoo (B2, B4) complies. The results of WV interoperated in statically T-test, Quality Control (±3 s analysis) & the results implicated deviating from the control, specification limits. These tests bring out the errors, misbranded and bad quality of markedly available products & there is a need to improve regulatory standards to ensure the therapeutic and quality goals.
Keyword: Siddha Mathirai, Disintegration, Weight Variation, Siddha Tablet, Market Samples. INTRODUCTION Siddha medicine, traditional system of healing that originated in South India and is marked to be one of India’s oldest systems of medicine. Siddha medicine is of Dravidian origin, has its entire literature in Tamil language and practitioners of Siddha medicine are known as Siddhars.[1] This system is based on a combination of ancient medicinal practices and spiritual disciplines as well as mysticism and alchemy.[2] Unlike Ayurveda, which is another traditional system of Indian medicine, but which gives topmost priority to herbal treatment, Siddha medicine gives importance to the conjunctive use of plants and minerals. For simple ailments, initial use of herbs is advised and if this does not prove effective, the judicious use of plants, minerals, and animal products will be recommended. [3],[4] Siddha system of medicines which include various kinds of dosage forms like mathirai, Parpam, Chooranam, Thylam, Kudineer, Mezhugu, Kalimbu etc. among all the dosage forms the most common form of the oral route administration which comes on mind are the tablets which have the most substantial and significant place among
DOI: https://doi.org/10.31838/ijpr/2019.11.03.009
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