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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Methanol Extract of Barks of Anogeissus Latifolia: Appraisal of Antidiabetic Potential in D-Variant Encephalomyocarditis Virus-Induced Diabetes

Author: PRATEEK BISHT, CHANDRASHEKHARA S , SOURAV TRIBEDI
Abstract: Anogeissus latifolia Wall (Combretaceae) is a bulky or fair-sized tree existing all over India. The plant is traditionally utilized for various ailments including dysentery, hepatopathy, snakebite, leprosy, wounds, ulcers, skin diseases and diabetic conditions. The current study meant to evaluate the antidiabetic prospective of the methanol extract of barks of Anogeissus Latifolia in D-EMC virus-induced diabetes. The D variant of EMC virus was utilized to infect the mice for induction of pancreatic beta cell damage leading to diabetes. Diabetes was established by estimating the serum glucose levels. The confirmed diabetic animals were further assembled in groups and utilized for the study. Various other biochemical markers were also evaluated which include insulin, liver glycogen, leptin, testosterone and glucagon levels. Liver functions and lipid profile were also measured. The results demonstrated potential antidiabetic efficacy of the methanol extract at both the dose level of 200 and 400 mg/kg. In conclusion, the methanol extract of barks of Anogeissus Latifolia was established to be significant antidiabetic.
Keyword: Anogeissus Latifolia, virus-induced diabetes, diabetes, encephalomyocarditis, plaque forming units.
DOI: https://doi.org/10.31838/ijpr/2019.11.02.104
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