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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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FORMULATION AND EVALUATION OFAN EMULGEL OF A BCS CLASS II DRUG

Author: MAYANK SAINI, SHEETAL SINGH, SUSHMA VERMA
Abstract: The purpose of this research work has been made to prepare and characterized ketoconazole emulgel by using two type of polymer that are as Carbopol 934(synthetic polymer) and Xanthum gum ( natural polymer). Effect of the type of gelling agent and the concentration of oil phase and emulsifying agent in the prepared emulgel was investigated by the 23 factorial designs Now days, the topical preparation emulgel is one of the most promising dosage form which gives better patient compliance. Mostly the emulgel was formulated by using carbolpol and methyl cellulose, but in this Project ketoconazoleemulgel was formulated as topical preparation using two type of polymer carbopol 934 and xanthum gum. In this research 8 formulations were formulate namelyM1, M2, M3, M4, M5, M6, M7 & M8 using two polymers. All formulation contains (+2.5% to -1.5%) emulsifying agent (+7.5% to -5%) oil concentration. And each prepared emulgel wascharacterized by various parametersthat are as pH, rheological studies, spreadability, viscosity & drug content. Among the eight formulations the best one was selected on the basis of drug content & drug release parameters M5 was found to be the best one. Stability studies showed that the physical appearance, rheological study and in vitro drug release in all the prepared emulgel remained unchanged upon storage for 3 months.It was suggested that the emulgel formulation achieve the desired drug release for sustained drug delivery in a controlled manner.
Keyword: Emulgel, ketoconazole, Carbopol, Xanthan gum,
DOI: https://doi.org/10.31838/ijpr/2019.11.02.103
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Impact Factor for five years is 1.55 (2012 - 2016)

Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477