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Physical Stability and in vivo Safety Evaluation of Stable Cream Containing Lakka-Lakka (Curculigo orchioides Gaertn.) and Albumin
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| Author:
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AISYAH FATMAWATY, NURUL A YUSUF, ZULHAM, ANDI NUR AISYAH, LUKMAN MUSLIMIN
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| Abstract:
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While the skin has its own defense mechanism, chronic exposure to ultraviolet radiation may contribute to its
hyperpigmentation and premature aging. For this reason, a water-in-oil anti-aging and whitening cream emulsion with
albumin as an ingredient is often developed (Curculigo orchioides Gaertn) for protection. The ingredients used include
tween 60 and span 60 as an emulsifier with concentration: 4 (F1); 5 (F2); and 6% (F3). This study, therefore, examined
the physical stability comprising of organoleptic, homogeneity, pH, and type of emulsion, adhesive test, spreadability,
and viscosity. Safety in vivo of the stable formulation, irritation, allergy, and photosensitivity carried out on rabbits. The
results showed that only F1 meet the physical stability and was considered non-irritant according to in vivo test. A
formulation containing C. orchioides and albumin could be considered safe for cosmetic use since it passed the toxicity
tests.
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| Keyword:
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Physical Stability, Safety evaluation, Stable Cream
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.02.099
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| Download:
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Request For Article
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