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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Physical Stability and in vivo Safety Evaluation of Stable Cream Containing Lakka-Lakka (Curculigo orchioides Gaertn.) and Albumin

Author: AISYAH FATMAWATY, NURUL A YUSUF, ZULHAM, ANDI NUR AISYAH, LUKMAN MUSLIMIN
Abstract: While the skin has its own defense mechanism, chronic exposure to ultraviolet radiation may contribute to its hyperpigmentation and premature aging. For this reason, a water-in-oil anti-aging and whitening cream emulsion with albumin as an ingredient is often developed (Curculigo orchioides Gaertn) for protection. The ingredients used include tween 60 and span 60 as an emulsifier with concentration: 4 (F1); 5 (F2); and 6% (F3). This study, therefore, examined the physical stability comprising of organoleptic, homogeneity, pH, and type of emulsion, adhesive test, spreadability, and viscosity. Safety in vivo of the stable formulation, irritation, allergy, and photosensitivity carried out on rabbits. The results showed that only F1 meet the physical stability and was considered non-irritant according to in vivo test. A formulation containing C. orchioides and albumin could be considered safe for cosmetic use since it passed the toxicity tests.
Keyword: Physical Stability, Safety evaluation, Stable Cream
DOI: https://doi.org/10.31838/ijpr/2019.11.02.099
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