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Pharmacological evaluation of the efficacy of metabolic drugs for acute biliary pancreatitis
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| Author:
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TETIANA POTAPOVA*, OLENA KOVALENKO, ANNA PROKHACH, VALENTYNA OPRYSHKO, HANNA PELESHENKO, DMYTRO BAS
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| Abstract:
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Rate of acute pancreatitis is up to 40 cases per year per 100,000 adults, while about 10-15% of patients have severe
forms of this disease, among which the mortality rate reaches 80%. Aim: to experimentally evaluate the
pharmacological efficacy of the combined use of drugs (immunomodulators, antioxidants and membrane protectors)
in acute biliary pancreatitis with a high degree of severity.A laboratory rat population was used for the study. 210
animals were divided into 3 groups. Group 1 did not receive any drugs, group 2 received a combination of ferrovir,
mexidol and phosphogliv, and group 3 received a combination of polyoxidonium and Essentiale N. Before and after
the administration of drugs combination, the indicators of the immunological status and parameters of the oxidative
system were evaluated.Combination of ferrovir, mexidol and phosphogliv with mild pancreatitis corrects 12.0% and
normalizes 75% of the studied laboratory immune and oxidative indices, respectively. With a moderate degree of
pancreatitis, these indicators were 19.2% and 45%, and with a severe degree, corresponding to the control values. For
group 3, drug combination leads to normal laboratory values of immune and oxidative status in mild pancreatitis, with
moderate severity it normalizes 27% and correlates in 73% of cases, and with severe severe it correlates with all
studied results.As established experimentally, mild forms of biliary pancreatitis are completely corrected with
different drug combinations. With moderate and severe severity, there are immunometabolic disorders recorded.
The combination proposed in this case is neither sufficiently effective nor ineffective.This study has convincingly
proved the relevance of drug treatment of mild biliary pancreatitis with drug combination on the example of
laboratory animals. At the same time, drug treatment is ineffective for moderate and severe pancreatitis. The study
requires the continuation and testing of the resulting drug combination for mild biliary pancrea
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| Keyword:
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biliary pancreatitis; ferrovir, mexidol, phosphogliv, polyoxidonium, Essentiale N, combination
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.01.305
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| Download:
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