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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Detection of FOXP3 gene expression in patients with Epstein– Barr Virus

Author: RAWAQ ALMEHANYAH, SIHAM JASIM ALKAABI
Abstract: The virus switch from latency state to the lytic cycle lead to an increase incidence B malignancies when failure the immune system to control on B cells after reactivation of the virus. The aimed of this research is determination the seroprevalence of EBV and evaluate the role of EBV that may be related to chronic diseases by diagnosis of EBV VCA IgG, EBV VCA IgM in serum patients with EBV and detect the role of regulatory T cells in the regulation of immune response in positive EBV patient by measurement gene expression of transcription factor of FOXP3. The research consists of 79 samples infected with EBV and divided into 2 groups (31 Hodgkin lymphoma, 48 symptoms) and 41 healthy divided into 2 groups (24 seropositive and 17 control) after diagnosis of EBV VCA IgG, EBV VCA IgM by using ELISA assay. The results obtained that, The level of IgM was high prevalence in Symptoms group at a percentage (6.25%) while the absence of this antibody in other 3 groups at a rate (0.0%). as well as the elevated level of IgG in Seropositive at a rate (58.53%) while decline this antibody in symptoms group at ratio (41.66%). also, the mean of Foxp3 significantly increased in Hodgkin lymphoma (28.95±12.91) and insymptoms group(22.23±10.34)compared with other two groups.
Keyword: FOXP3, EBV, Hodgkin lymphoma.
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