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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Effect of High Interval Intensity Exercise (HIE) in Hypoxia and Normoxia Conditions on the Serum of Vascular Endothelial Growth Factor (VEGF) Response in Non-Athletic Men

Author: VAHID KHAKIYAN
Abstract: Angiogenesis refers to the biological process in which new blood vessels branch off from pre-existing vessels in the tissue. Angiogenesis is vital for organogenesis as well as cellular proliferation and differentiation during fetus development. This phenomenon has also been observed in humans and mature animals which can be categorized into physiological and pathophysiological forms. The purpose of this study is to determine the effect of high interval intensity exercise (HIE) on serum VEGF of non-athletic men in hypoxia and normoxia conditions. To this end, 9 young non-athletic men are selected as our participants. The average of their age, height, and weight are 24.50±50 year, 174.22±4.60 cm and 70.75±4.53 kg, respectively. According to our calculation, their maximum working efficiency (Wmax) in hypoxia condition is 185±29.04 and in normoxia condition is 200.00±31.81. First, participants carried out high-intensity exercise protocol in normobaric hypoxia condition (oxygen percentage ranged from 15.3% to 15.5% and height is 2500 meters) and then they performed this protocol in normoxia condition after one week. Blood samples were taken before the exercise as well as immediately and 2 hours after the exercise. From the results of one-way analysis of variance (ANOVA) with repeated measurements, it can be concluded that there is no remarkable difference in the amount of influence on the serum level of VEGF in non-athletic men during various environmental conditions (hypoxia and normoxia). Although there was no significant difference between different environmental conditions (hypoxia and normoxia) of this paper, it is essential to note that the serum level of VEGF was increased by 38% and 14% immediately after performing a high interval intensity training (HIT) in hypoxia and normoxia conditions, respectively. Findings of this article showed that the high interval intensity training leads to the rise in the serum level of vascular endothelial growth factor in normoxia (not significant) and hypoxia (significant) condition. Exercise interventions and extensive research are required to identify angiogenesis in the body. Although the high levels of VEGF after high-intensity exercises may lead to an increase in angiogenesis, future studies are needed to determine stimuli as well as mechanisms for growing new blood vessels reported during the high-intensity exercises.
Keyword: Angiogenesis, Hypoxia, Normoxia, Men, Athlete
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