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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Effect of Prenatal Infusion of Magnesium Sulphate on Neurological Complication in Preterm Infant

Author: HALSHO MUHAMMED, SRWA JAMAL MURAD
Abstract: Preterm infants are infants who are born more than 24 weeks of gestation but less than37 weeks. With the advances of medicine the survival rate of this infants have increased. But increase in neurological abnormalities is a matter of concern. Some studies shows that intravenous administration of magnesium sulphate has neuroprotective effect. To asses nueroprotictive effect of maternal intravenous administration of magnesium sulphate on neurological outcome of neonates in preterm deliveries In a randomized controlled trail 60 mothers divided in to two groups of 28 and 32 cases were included in this study. The first group received intravenous magnesium sulphate, the second received just normal saline. Follow up of the babies was done for 28 days postnatal. Ultrasound of brain performed at seven days and at 28 days postnatal a pediatrician viewed the neonate to assess the presence of any neurological abnormality.The Apgar score for the group who received the drug was more both at one and five minutes. Mortality rate in this group was (3.5%) at the time the group with placebo had mortality rate of (22%) (Pvalue was 0.02) , duration of the intensive care unit stay was less in the first group Intraventricular hemorrhage was present in 1 case of the second group. Intravenous magnesium administration is cost effective as saved 40000 $ during the period of follow up. Magnesium sulphate has neuroprotective effect on neonate. There was decrease in mortality in the group who received it. Duration of the intensive care unit stay was less, too. Larger sample size may be necessary to have a better estimate of outcome.
Keyword: Magnesium sulphate, neonatal care unit (NCU), Cerebral Palsy (CP), APGAR Score, Cost-effectiveness
DOI: https://doi.org/10.31838/ijpr/2019.11.03.005
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