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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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The value of diclofenac gel 1 % in the treatment of pityriasis versicolor in a sample of Iraqi patients

Author: ASMAA JALEEL, AKEEL HAMED JABUR
Abstract: One of the commonly encountered skin disorders seen in daily clinical practice is the benign superficial fungal skin infection known as tinea versicolor or pityriasis versicolor. Clinically it presents as macules with fine scales that are either hypopigmented or hyperpigmented involving most often the neck, upper extremities, and the trunk. However, because of the high rate of recurrence and frequent failure of response accompanying usual mode of treatment, several agents are tried now and then, and one of these agents that have been evaluated for treating tinea versicolor is topical 1% diclofenac gel. In the current randomized controlled clinical trial we are aiming to compare the response of tinea versicolor to diclofenac gel in comparison with clotrimazole cream in a sample of Iraqi patients suffering the disease. The present randomized controlled clinical trial included 40 tineaVersicolor patients with an age range of 19 to 42 years. Those patients were randomly selected from the pool of patients visiting the dermatology department at Al-Diwaniyah teaching hospital in Al-Diwaniyah province, Mid-Euphrates region of Iraq. Patients were diagnosed by dermatology specialist and were randomly allocated into two groups, 20 patients each. The first group served as a study group, and the patients received 1% diclofenac gel based ontwo times a day for one month. Patients in the second group, the control group, were given the usual clotrimazole cream, two times daily for one month. There was a highly significant difference in response to treatment between both groups two weeks after surgery in such a way that clotrimazole resulted in more complete response than diclofenac gel, 65 % versus 20 %, respectively (P = 0.008). Moreover, there was a significant difference in response to treatment between both groups four weeks after treatment in such a way that clotrimazole resulted in more complete response than diclofenac gel, 90 % versus 50 %, respectively (P = 0.019).It appears that diclofenac topical 1% gel is fairly effective in the treatment of pityriasis versicolor; however, other agents such as clotrimazole are more effective, and hence diclofenac topical 1% gel may be used as an adjuvant form of treatment rather than the sole treatment modality.
Keyword: Diclofenac 1 % gel, pityriasis Versicolor, clotrimazole
DOI: https://doi.org/10.31838/ijpr/2019.11.03.004
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