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N-acetylcysteine in addiction management: current knowledge and future perspectives
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| Author:
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AMIR GHADERI, NEDA VAHED, RAOOFEH GHAYOOMI, VAHIDREZA OSTADMOHAMMADI, MOSTAFA GHOLAMI, SOMAYEH GHADAMI DEHKOHNEH
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| Abstract:
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Drug abuse disorders and addictive behaviors are serious public health problems and major contributors to the global
burden of disease. Previous studies show that N-acetylcysteine (NAC) may be involved in neurodevelopment adult
brain. The potential neuroprotective effect of NACis associated with modulate several neurological pathways,
including prevention of oxidative stress or inflammation damage to nervous tissue and glutamate dysregulation, NAC
is being explored as an adjunctive therapy for drug addiction and addiction management.We here review the role of
NAC in the addiction, such as cannabis abuse, methamphetamine abuse, cocaine addiction, nicotine dependency, and
gambling.Adequate administrate of NAC seems to be crucial in terms of addiction management. NAC is safe and well
tolerated when administered orally but has documented risks with intravenous administration. An evidence study
supports its use as an adjunctive therapy clinically for drug addiction, administered concomitantly with existing
medications. The aim of this review is to assess the current knowledge related to the role of NAC administration on
drug addiction and addiction management.
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| Keyword:
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N-acetylcysteine (NAC), drug addiction, addiction management
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.03.003
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| Download:
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