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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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N-acetylcysteine in addiction management: current knowledge and future perspectives

Author: AMIR GHADERI, NEDA VAHED, RAOOFEH GHAYOOMI, VAHIDREZA OSTADMOHAMMADI, MOSTAFA GHOLAMI, SOMAYEH GHADAMI DEHKOHNEH
Abstract: Drug abuse disorders and addictive behaviors are serious public health problems and major contributors to the global burden of disease. Previous studies show that N-acetylcysteine (NAC) may be involved in neurodevelopment adult brain. The potential neuroprotective effect of NACis associated with modulate several neurological pathways, including prevention of oxidative stress or inflammation damage to nervous tissue and glutamate dysregulation, NAC is being explored as an adjunctive therapy for drug addiction and addiction management.We here review the role of NAC in the addiction, such as cannabis abuse, methamphetamine abuse, cocaine addiction, nicotine dependency, and gambling.Adequate administrate of NAC seems to be crucial in terms of addiction management. NAC is safe and well tolerated when administered orally but has documented risks with intravenous administration. An evidence study supports its use as an adjunctive therapy clinically for drug addiction, administered concomitantly with existing medications. The aim of this review is to assess the current knowledge related to the role of NAC administration on drug addiction and addiction management.
Keyword: N-acetylcysteine (NAC), drug addiction, addiction management
DOI: https://doi.org/10.31838/ijpr/2019.11.03.003
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