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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Antianaphylactic Activity Polyherbal Formulation Against Systemic, Cutaneous And Compound 48/80 Induced Invitro Anaphylaxis

Author: DR GIRISH, C. GIRISH, PROF. Y. NARSIMHA REDDY
Abstract: Anaphylaxis is an acute hypersensitive reaction, which is produced by the release of different chemical mediators from mast cells. Alteration in physiology of mast cell is responsible for the various physiological changes during anaphylaxis. Objective of this study was to evaluate the Invivo and Invitro antianaphylactic activity of polyherbal formulation against the systemic anaphylaxis, cutaneous anaphylaxis and compound 48/80 induced invitro anaphylaxis with the help of rat mesenteric mast cells. The study was carried out by compound 48/80 induced systemic anaphylaxis model, compound 48/80 induced cutaneous anaphylaxis model and compound 48/80 induced invitro anaphylaxis model. In compound 48/80 induced systemic anaphylaxis model, rats are sensitised by intraperitoneal administration of compound 48/80 and they were monitored for anaphylactic shock. In compound 48/80 induced cutaneous anaphylaxis model, rats are sensitised by subcutaneous administration of compound 48/80, and they were observed for the scratching behaviour. In compound 48/80 induced invitro anaphylaxis model, compound 48/80 was added to the petridishes containing mesenteric pieces and they were observed for intact mast cells. The rats which are pretreated with polyherbal formulation (250 mg) and standard drugs like Disodium chromoglycate, prednisolone shows beneficial effect against anaphylaxis. Antianaphylactic activity of polyherbal formulation may be possibly due to the membrane stabilizing potential.
Keyword: Mast cell degranulation, Membrane stabilization, systemic anaphylaxis, Cutaneous anaphylaxis, Polyherbal formulation
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0.12
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