Impact Factor for Five Years is 1.55 (2012 - 2016). 22nd National Convention of Society of Pharmacognosy & International Conference. For more details visit https://ncsp.ganpatuniversity.ac.in/index.php

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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

ISSN
0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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Article In Press
Antioxidant activity and total phenolic content in 15 commonly used cucurbits in Tarai region of Kumaun, Uttarakhand.
Analytical Method Development and Validation for the Simultaneous Estimation of Ambroxol Hydrochloride and Guaiphenesin in Syrup Dosage form by RP-HPLC
Role of NMDA receptor antagonist in ethanol withdrawal syndrome
STABILITY INDICATING LC-MS/MS METHOD FOR QUANTIFICATION OF IBRUTINIB IN HUMAN PLASMA
A review on drug: Amantadine
Chemopreventive and antioxidative activity of Carissa carandas extract against chemical induced skin tumorigenesis in mice
ROLE OF AMIODARONE IN ACUTE MYOCARDIAL INFARACTION INDUCED VENTRICULAR TACHYCARDIA IN PATIENTS WITH LEFT ANTERIOR DESCENDING ARTERY INVOLVEMENT
Extraction optimisation, fractionation, standardisation, in vitro antioxidant and anticholinesterase activity of fractions of Indian Propolis
Development of validated stability-indicating analytical method for simultaneous estimation of Atenolol and Hydrochlorothiazide in pharmaceutical combined dosage form by High Performance Thin Layer Chromatography.
Lung Cancer in Lifelong Never Smokers-Short Review
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IJPRT ISSUE

January - March 6 [1] 2014

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Article Detail

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Antianaphylactic Activity Polyherbal Formulation Against Systemic, Cutaneous And Compound 48/80 Induced Invitro Anaphylaxis

Author: DR GIRISH, C. GIRISH, PROF. Y. NARSIMHA REDDY
Abstract: Anaphylaxis is an acute hypersensitive reaction, which is produced by the release of different chemical mediators from mast cells. Alteration in physiology of mast cell is responsible for the various physiological changes during anaphylaxis. Objective of this study was to evaluate the Invivo and Invitro antianaphylactic activity of polyherbal formulation against the systemic anaphylaxis, cutaneous anaphylaxis and compound 48/80 induced invitro anaphylaxis with the help of rat mesenteric mast cells. The study was carried out by compound 48/80 induced systemic anaphylaxis model, compound 48/80 induced cutaneous anaphylaxis model and compound 48/80 induced invitro anaphylaxis model. In compound 48/80 induced systemic anaphylaxis model, rats are sensitised by intraperitoneal administration of compound 48/80 and they were monitored for anaphylactic shock. In compound 48/80 induced cutaneous anaphylaxis model, rats are sensitised by subcutaneous administration of compound 48/80, and they were observed for the scratching behaviour. In compound 48/80 induced invitro anaphylaxis model, compound 48/80 was added to the petridishes containing mesenteric pieces and they were observed for intact mast cells. The rats which are pretreated with polyherbal formulation (250 mg) and standard drugs like Disodium chromoglycate, prednisolone shows beneficial effect against anaphylaxis. Antianaphylactic activity of polyherbal formulation may be possibly due to the membrane stabilizing potential.
Keyword: Mast cell degranulation, Membrane stabilization, systemic anaphylaxis, Cutaneous anaphylaxis, Polyherbal formulation
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News & Events
22nd National Convention of Society of Pharmacognosy & International Conference. For more details visit https://ncsp.ganpatuniversity.ac.in
Impact Factor for five years is 1.55 (2012 - 2016)
Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477
Impact Factor for five years is 1.3 (2010 - 2014)