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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Ameliorative Role Of Green Tea Against Cytophosphane Induced Genetic And Hepato-Toxicity In Male Rats

Author: SHENOUDA GIRGIS, AMIRA ABD ELRAOUF, HALIMA S ABDOU
Abstract: The present study was aimed to investigate the toxicity of chemotherapeutic drug cytophosphane (CTX) and possible protective effect of green tea extract (GTE) on CTX induced genetic toxicity and group was divided into 6 subgroups (5 animals each), 3 subgroups were treated with 50, 100, 200 mg/kg bw of CTX, the other 3 subgroups were treated with the same doses of CTX plus GTE hepatic injury of male albino rats. Hundred adult male albino rats were divided into four groups. The first for 7 days. The 2nd and the 3rd groups were received the same treatment of the 1st group but for 15 and 30 days, respectively. The 4th group received an intraperitoneal (i.p.) injection of physiological saline as vehicle and served as the control. Chromosomal aberrations, RNA, DNA and protein levels as well Bilirubin, GPT(glutamate pyruvate transaminase), Alkaline phosphatase (ALP) and GOT (glutamate oxaloacetate transaminase) for liver function were determined. The results of the present study revealed that CTX treatment increased chromosomal aberration frequency in rat bone marrow cells that include gaps, centromeric attenuations, deletions, fragments, endomitosis and total aberrations especially with 15 and 30 days of treatment compared to control. However, green tea supplementation ameliorate these levels. DNA and protein levels were decreased significantly as a sequence of CTX treatment compared to control. However, green tea supplementation improves these levels. RNA content was not significantly affected by CTX treatment compared to control.CTX administration significantly increased the levels of glutamate pyruvate transaminase (GPT),glutamate oxaloacetate transaminase (GOT), Bilirubim and alkaline phosphatase (ALP) when compared to control animals, while green tea administration significantly decreased these levels. In conclusion the finding of this study suggested that green tea extract has strong protective effect against CTX induced genetic and hepatic-toxicity. The antioxidant effect of green tea could significantly inhibit the free radical generation which causes toxicity. This study also shows that green tea has its place in both the conventional and alternative medical communities.
Keyword: Cytophosphane , Genotoxicity, Hepatotoxicity, DNA, RNA, Protein and Rat
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