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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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Total Publications: 317

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Synthesis, Antimicrobial and Antitubercular Activity of Some Pyrazoline Derivatives from Chalcones of indane-1,3-dione

Author: SIDDHARTH DESAI, DR. V.GIRIJA SASTRY
Abstract: We synthesized a series of pyrazolines from chalcones of indane-1,3-dione.In turn chalcones were prepared by reacting 2- acetyl indane-1,3-dione with different aromatic aldehydes in the presense of ethanolic sodium hydroxide(reported by us) [1,2] .The new pyrazoline derivatives were synthesized by condensation of chalcones of indane-1,3-dione with hydrazine hydrochloride in basic medium viz. pyridine in the presense of ethanol. The newly synthesized compounds(6a-f) have been characterized by IR (Infra red) Spectroscopy and 1NMR (Nuclear Magnetic Resonance) Spectroscopy and TLC (Thin Layer Chromatography). these new compounds have been evaluated for their antibacterial, antifungal and antitubercular activities.
Keyword: Chalcone, aromatic aldehydes,pyrazole, antimicrobial and antitubercular activity.
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22nd National Convention of Society of Pharmacognosy & International Conference. For more details visit https://ncsp.ganpatuniversity.ac.in
Impact Factor for five years is 1.55 (2012 - 2016)
Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477
Impact Factor for five years is 1.3 (2010 - 2014)