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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
ISSN
0975-2366
5 - Years Impact Factor

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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January - March 6 [1] 2014

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Synthesis, Antimicrobial and Antitubercular Activity of Some Pyrazoline Derivatives from Chalcones of indane-1,3-dione

Author: SIDDHARTH DESAI, DR. V.GIRIJA SASTRY
Abstract: We synthesized a series of pyrazolines from chalcones of indane-1,3-dione.In turn chalcones were prepared by reacting 2- acetyl indane-1,3-dione with different aromatic aldehydes in the presense of ethanolic sodium hydroxide(reported by us) [1,2] .The new pyrazoline derivatives were synthesized by condensation of chalcones of indane-1,3-dione with hydrazine hydrochloride in basic medium viz. pyridine in the presense of ethanol. The newly synthesized compounds(6a-f) have been characterized by IR (Infra red) Spectroscopy and 1NMR (Nuclear Magnetic Resonance) Spectroscopy and TLC (Thin Layer Chromatography). these new compounds have been evaluated for their antibacterial, antifungal and antitubercular activities.
Keyword: Chalcone, aromatic aldehydes,pyrazole, antimicrobial and antitubercular activity.
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Ulrich's International Periodical Dictionary
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News & Events
Impact Factor for five years is 0.973 (2009 - 2013)
Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477
Impact Factor for five years is 1.3 (2010 - 2014)