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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Synthesis, Antimicrobial and Antitubercular Activity of Some Pyrazoline Derivatives from Chalcones of indane-1,3-dione

Author: SIDDHARTH DESAI, DR. V.GIRIJA SASTRY
Abstract: We synthesized a series of pyrazolines from chalcones of indane-1,3-dione.In turn chalcones were prepared by reacting 2- acetyl indane-1,3-dione with different aromatic aldehydes in the presense of ethanolic sodium hydroxide(reported by us) [1,2] .The new pyrazoline derivatives were synthesized by condensation of chalcones of indane-1,3-dione with hydrazine hydrochloride in basic medium viz. pyridine in the presense of ethanol. The newly synthesized compounds(6a-f) have been characterized by IR (Infra red) Spectroscopy and 1NMR (Nuclear Magnetic Resonance) Spectroscopy and TLC (Thin Layer Chromatography). these new compounds have been evaluated for their antibacterial, antifungal and antitubercular activities.
Keyword: Chalcone, aromatic aldehydes,pyrazole, antimicrobial and antitubercular activity.
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