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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Design and Development of Polyherbal Cream for skin repigmentation therapies in Vitiligo

Author: VINEET JAIN, BHAVESH V AKBARI, GAUTAM SONARA, KAUSHAL VIRADIYA, HETAL BHENJALIYA
Abstract: Vitiligo is an inflammatory condition associated with painful itchy, scaly skin & disfiguring skin lesion. The lack of possible care and associated disadvantage in allopathic medicine has led to extensive research in natural product with anti-psoriatic activity. Psoralea corilyfolia [Babchi oil], Aloe barbadensis (Aloe Vera leaves), Ocimum sanctum (Tulsi-leaves), Azadirachta indica (Neem-leaves), Curcuma longa (Turmeric-rhizomes), Ammi visnaga (Ammi fruits), Citrus limonum (Lemon Peel), Citrus sinensis (Orange Oil), were found to be efficacious and cheap anti-inflammatory drugs with least side effects as compared to synthetic drugs used in treatment of vitiligo. The aim of the present research was to formulate the herbal Cream for the purpose of skin repigmentation therapies in vitiligo, therefore these drugs were selected for present study. Considering the above justification an attempt was made to design & develop polyherbal cream. Different crude drugs extracts were taken & poly herbal cream was prepared. Accelerated stability testing of two final sample has been conducted in the environmental chamber with temperature 25 ± 10C and humidity 60 ± 10% RH. All the products were found to be stable with no sign of phase separation and no change in the color. The patch test for sensitivity testing has also been done and no evidence of skin irritation and allergic signs. This work mainly focuses on the assessment of the microbial quality of Formulated cosmetic preparations. To the surprise, both formulations was found to comply with the microbial limit tests as per the international specifications
Keyword: Polyherbal Cream, Skin repigmentation therapies, Vitiligo
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