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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

ISSN
0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

Current Issue
22nd NATIONAL CONVENTION

22nd National Convention of Society of Pharmacognosy & International Conference. For more details visit


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Article In Press
Biomechanical/biochemical factors contributing to cardiac fibrosis in the heart and engineered cardiac tissue
THE ASSOCIATION AND LINKGAGE OF VARIOUS RETROVIRUSES AND ITS PROGRESSION TOWARDS NEURODEGENERATION
Architecture of Viral RNA Helicases; HCV helicase as Antiviral Target
GC-MS analysis of rhizome extract by Cold maceration of Curcuma amada Roxb.
Development and Evaluation of Febuxostat Sublingual Tablet Formulation
Development and Evaluation of Febuxostat Sublingual Tablet Formulation
A comparative study of adaptogenic effect of Withania somnifera with Mifepristone (a GR antagonist) on chronic stress - induced perturbations in glucose metabolism
In Vitro Anticancer Activity Of Leaves Of Rumex Vesicarius Linn And Symplocos Racemosa Roxb By Trypan Blue Method
PREPARATION AND INVITRO CHARACTERISATION OF ANTIBACTERIAL NANOCAPSULES
Cytotoxic potential of the crude solvent extract of Botryodiplodia theobromae – an endophytic fungi isolated from Catharanthus roseus.
12
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IJPRT ISSUE

January - March 6 [1] 2014

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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Article Detail

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Formulation, In-vitro Evaluation and Optimization of Nanoemulsion of Raloxifene Hydrochloride

Author: NARENDRA CHOTAI, BINAL R. PANDYA, RAJNIKANT M. SUTHAR, HARDIK K. PATEL
Abstract: The aim of the present work was to prepare nanoemulsion of raloxifene hydrochloride by high pressure homogenization method with a view to enhance its solubility and dissolution. The solubility of drug was determined in different oils, surfactants and co-surfactants. Pseudoternary phase diagrams were plotted on the basis of solubility data of drug in various components to evaluate the nanoemulsification region. The capmul MCM C8, tween 20 and propylene glycol were selected as the oil, surfactant and co-surfactant respectively for the formulation development. A box-behnken design was adopted for the preparation nanoemulsion possessing optimized characteristics. Concentration of oil (X1), concentration of Smix (X2), and homogenization pressure (X3) were selected as independent variables whereas globule size and cumulative % drug release after 24 hrs (Q24) were selected as dependent variables. Total fifteen batches (B1 to B15) were formulated and evaluated for different parameters such as globule size, polydispersibility index (PDI), drug content, % transmittance, refractive index (RI), pH, viscosity, in-vitro drug release study, zeta potential and transmission electron microscopy. Amongst all prepared batches B12 (oil-15%, Smix-50% and 35% water) showed satisfactory results of globule size and in-vitro drug release and it can be considered as optimized formulation. It was compared with marketed product and pure drug for their in-vitro release study and found to be promising formulation.
Keyword: Nanoemulsion, Phase diagram, Globule size, Zeta potential, Box-behnken design.
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News & Events
22nd National Convention of Society of Pharmacognosy & International Conference. For more details visit https://ncsp.ganpatuniversity.ac.in
Impact Factor for five years is 1.55 (2012 - 2016)
Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477
Impact Factor for five years is 1.3 (2010 - 2014)