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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
ISSN
0975-2366
5 - Years Impact Factor

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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January - March 6 [1] 2014

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Article Detail

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SOLUBILITY ENHANCEMENT OF ACYCLOVIR BY SOLID DISPERSION METHOD

Author: ARAVINDA ARAVINDA NALLA, KRISHNA MOHAN CHINNALA
Abstract: Acyclovir is a popular anti-Herpes drug among the antiviral category for the treatment of diseases including Herpes simplex (type 1) Keratitis etc. Acyclovir is the drug of choice for most of these cases but the problem of using this drug is that it has poor oral bioavailability. The conventional routes and therapies available for the treatment of Herpes, Keratitis, includes orally administered tablet but are associated with it is very low bioavailability ranging from 15-30%. Repeated administration of high doses result in infrequent nausea, diarrhoea, rash, and headache. This problem can be resolved by enhancing the solubility and hence dissolution of poorly water soluble drug acyclovir. The aim of the present study was to formulate and evaluate Acyclovir solid dispersions by gel entrapment method using HPMC E5 and HPMC E15 in the ratios of 1:1, 1:2 and 1:3. The prepared solid dispersions were evaluated for FTIR studies, DSC, drug content, drug release studies and aqueous solubility studies. Acyclovir solid dispersions releases the drug up to 96% for one hour in 0.1 N HCl, the drug content was found to be maximum as 98% and the solubility6 of Acyclovir was increased by formulating into solid dispersions.
Keyword: Acyclovir, keratitis, solubility, dissolution, bioavailability, solid dispersion, gel entrapment.
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Ulrich's International Periodical Dictionary
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News & Events
Impact Factor for five years is 0.973 (2009 - 2013)
Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477
Impact Factor for five years is 1.3 (2010 - 2014)