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Formulation and Evaluation of Polymer Carrier System for Venlafaxine Hydrochloride Rapid Disintegrating Tablet
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| Author:
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PARAG BAKSHE, PROF. (DR.) VIJAY R. PATIL, PROF. (DR.) RAJESH Y. CHAUDHARI, MR. SACHIN S. RANE
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| Abstract:
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Venlafaxine Hydrochloride, a novel antidepressant which used to treat psychosis is embedded as model drug in present investigation. In study we formulated mouth dissolving tablets of model drug by polymer carrier system with direct compression method using tableting aids and evaluated. The drug polymer complex was characterized for physical description, Bulk Density, Tapped Density, Compressibility Index, Hausner Ratio, Angle of Repose then subjected to FTIR studies and in vitro drug release studies. It was found that drug polymer complex P4 containing super disintegrant showed release within few seconds. The prepared tablets were evaluated for weight, thickness, hardness, friability, disintegration and drug dissolution of about 98 % achieved within 180 seconds. The prepared tablets stability tested at 40°C with Relative Humidity of 75 % for 3 months and they found to be stable in evaluation parameters.
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| Keyword:
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Venlafaxine, Rapid disintegrating, direct compression method, polymer carrier system
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| EOI:
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| DOI:
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