22nd National Convention of Society of Pharmacognosy & International Conference. AICTE Sponsored International Conference at Parul University.

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

ISSN
0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

Current Issue
22nd NATIONAL CONVENTION

22nd National Convention of Society of Pharmacognosy & International Conference. For more details visit


For More Detail Visit ncsp.ganpatuniversity.ac.in
Article In Press
Biomechanical/biochemical factors contributing to cardiac fibrosis in the heart and engineered cardiac tissue
THE ASSOCIATION AND LINKGAGE OF VARIOUS RETROVIRUSES AND ITS PROGRESSION TOWARDS NEURODEGENERATION
Architecture of Viral RNA Helicases; HCV helicase as Antiviral Target
GC-MS analysis of rhizome extract by Cold maceration of Curcuma amada Roxb.
Development and Evaluation of Febuxostat Sublingual Tablet Formulation
Development and Evaluation of Febuxostat Sublingual Tablet Formulation
A comparative study of adaptogenic effect of Withania somnifera with Mifepristone (a GR antagonist) on chronic stress - induced perturbations in glucose metabolism
In Vitro Anticancer Activity Of Leaves Of Rumex Vesicarius Linn And Symplocos Racemosa Roxb By Trypan Blue Method
PREPARATION AND INVITRO CHARACTERISATION OF ANTIBACTERIAL NANOCAPSULES
Cytotoxic potential of the crude solvent extract of Botryodiplodia theobromae – an endophytic fungi isolated from Catharanthus roseus.
12
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPRT ISSUE

January - March 6 [1] 2014

Click to download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Biocompatible novel carbohydrate polymer mannan sulphate: Biophysicochemical characterization and cytotoxicity evaluation

Author: VARSHA POKHARKAR, MEGHA V. MUGADE
Abstract: The carbohydrate polymers used in nanoparticles synthesis for targeted delivery is mainly preferred based upon their specificity and biocompatibility. The mannose receptor expression plays a pivotal role through strongest binding of sulphated polysaccharides with cysteine-rich (Cys-Rich) domain. In an effort to search biocompatible novel carbohydrate polymer for targeted drug delivery this study aims to synthesis and evaluation of sulphated polysaccharide mannan sulphate (MS). Mannan sulphate was synthesized from mannan isolated commercially from the cell wall of baker’s yeast (Saccharomyces cerevisiae).The mannan sulphate was characterized for percentage yield (86.66%), molecular weight determination (Mw=5.3 X 104 g/mol), degree of substitution (DS=1.23), total sugar and sulphate content (74.5±0.3% & 45.5± 1.3%) by using Ostwald method, elemental analyzer technique, phenol sulphuric acid method and Kawai method respectively. The protein content was estimated by Bradford method. Further, UV, FTIR and 13 C NMR were used for characterization of MS. The cytotoxicity studies were performed in cell lines such as murine macrophages J774A.1 cells, human skin fibroblasts TE 353.Sk cells and human keratinocytes HaCaT cells which exhibited a significant biocompatibility of mannan sulphate. This synthesis and cytotoxicity evaluation together could contribute to the development of biocompatible nanoparticles synthesis, which may aid in targeting drugs to specific parts of human body containing cells which expresses mannose receptor. This study concludes that mannan sulphate with interesting physicobiochemical properties may serve as valuable lead for nanoparticles synthesis for the treatment of human diseases.
Keyword: Mannan, Mannan sulphate, Carbohydrate polymer, MTT assay, biocompatible
Download: Request For Article
 












USER LOGIN
Username
Password
Login | Register
Forgot your password?
AICTE INTERNATIONAL CONFERENCE

AICTE Sponsored International Conference on Challenges, Opportunities and Newer Directions of Pharmacovigilance and Clinical Research in India

Download Brochure


For More Detail Visit www.pippharmacon.org
News & Events
22nd National Convention of Society of Pharmacognosy & International Conference. For more details visit https://ncsp.ganpatuniversity.ac.in
Impact Factor for five years is 1.55 (2012 - 2016)
Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477
Impact Factor for five years is 1.3 (2010 - 2014)