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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Formulation and Evaluation Considerations of Transdermal Drug Delivery System.

Author: UPLOADED BY-ADMIN, ASHOK H. BARIA, RAKESH P. PATEL
Abstract: Transdermal drug delivery systems, also known as ‘‘patches,’’ are dosage forms designed to deliver a therapeutically effective amount of drug across a patient’s skin. Structural and biochemical features of human skin and those characteristics which contribute to the barrier function and the rate of drug access into the body via skin play an important role. There are critically three ways in which a drug molecule can cross the intact stratum corneum: via skin appendages (shunt routes); through the intercellular lipid domains; or by a transcellular route. For successfully developing a transdermal drug delivery system, the drug should be chosen with great care. The following are some of the desirable properties of a drug for transdermal delivery. Basic components of transdermal drug delivery systems are release linear, backing, overlay, membrane, penetration enhancer and pressure sensitive adhesive. There are some problems with existing technology like variability in dosing, variation in temperature, physiological stress, skin irritation etc. This systemic review highlights advantages and disadvantages, basic component, types, problems and evaluation of Transdermal Drug Delivery System.
Keyword: Transdermal drug delivery systems (TDDS), Patches, Penetration enhancer.
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