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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Preparation and Thermo Stability Evaluation of Fish Liver Oil Emulsion Employing Various Emulsifying Agents

Author: UPLOADED BY-ADMIN, VIVEK SHRIVASTAVA, UPENDRA GUPTA, LIPI PURWAL, U K JAIN
Abstract: Emulsions are thermodynamically stable dispersions of immiscible liquids, such as oil and water, stabilized by an interfacial film of surfactant molecules. Cod liver oil is the natural remedy for the relief of joint pains and stiffness. Cod liver oil is quite unpleasant in taste because of which it is difficult for the patient to consume it orally. To hide its unpleasant taste and to increase patient compliance, we propose to formulate cod liver oil emulsion. The solutions of poly vinyl alcohol (PVA; 2%, 5% and 7%) and poly vinyl pyrolidone (PVP; 5%, 10 % and 15%) were prepared in distilled water and were employed as emulsifying agents. Similarly the combination solutions of both surfactants PVA and PVP were prepared (5% and 10 %). Effect of temperature (2-8oC, 40oC, 75% RH, 60oC, 75% RH and 80oC, 75% RH) on stability of prepared emulsions was also evaluated. PVA 2% was effective emulsifying agent for cod liver oil emulsion, while PVA 7% was found to be best emulsifying agent. The mixture PVA and PVP was not as effective as PVA 7% in stabilizing cod liver oil emulsion. PVA in concentration range 5 to 7% can be effectively used as emulsifying agent in cod liver oil emulsion preparation.
Keyword: Emulsion, Stability, Emulsifying agents, Cod liver oil
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