Impact Factor for Five Years is 1.55 (2012 - 2016). IJPRT Re-launched from 2017, for more details visit www.ijprtonline.com

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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
ISSN
0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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January - March 6 [1] 2014

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Article Detail

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3D-QSAR Studies CoMFA/CoMSIA and in silico docking studies on diverse structural classes of HIV-1 integrase inhibitors

Author: NEELAMMA MANTRI, ANUSHA VARANASI, VIJAYA LAKSHMI LOKIREVU, SESHAGIRI BANDI, AYUB SHAIK
Abstract: Combination of structure-based and ligand based drug design categeory, used to build 3D-QSAR model for a series of 37 experimentally known phthalimide derivatives. Comparative molecular field analysis (COMFA) and comparative molecular similarity indices analysis (COMSIA) methodologies were applied to a training set of 28 molecules and a test set of 9 molecules. The best statistical result of COMFA model gave r2 (non-cross validated square of r2= 0.984 and q2= 0.662, while for COMSIA r2= 0.967 and q2= 0.640. Predictive capability of these models supported by docking studies, produced better docking scores and binding affinity to the specified target HIV1 Integrase (1BLU).
Keyword: 3D-QSAR, COMFA, COMSIA, docking, phthalimide derivatives
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Scopus (Elsevier)
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Ulrich's International Periodical Dictionary
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News & Events
Impact Factor for five years is 1.55 (2012 - 2016)
Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477
Impact Factor for five years is 1.3 (2010 - 2014)