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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Antimicrobial and Antioxidant Evaluation of Some Novel Synthesized Pyridazinone Derivatives

Author: DINESH MEHTA, MINAXI SAINI, RINA DAS
Abstract: This study presents the synthesis and spectral analysis of novel pyridazinone derivatives. Cyclization reaction of mucochloric acid and semicarbazide hydrochloride in the presence of aqueous ethanol afforded 4,5-dichloro-2H-pyridazin-3-one (1). Novel compounds were synthesized by treating the 4,5-dichloro-2H-pyridazin-3-one (1) with substituted aldehyde and amine derivatives. All synthesized compounds were screened for their in vitro antibacterial, antifungal activities by using the agar cup plate method . The newly synthesized compounds showed antimicrobial activity against all the strains. Compounds 3b and 3c showed very good antifungal activity against candida albicans and Aspergillus niger (minimal inhibitory concentration [MIC] = 12.5 µg/mL). Some compounds showed good activity against Gram (+ve) bacteria and Gram (-ve) bacteria. Antioxidant study was done by using DPPH fee radical scavenging activity. Antioxidant activity assay showed that compound 3b had highest scavenger activity.
Keyword: Pyridazinone, antibacterial activity, antifungal activity, antioxidant
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