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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Development and Characterization of Once a Daily Tablet Formulation of Aceclofenac

Author: UPLOADED BY-ADMIN, PUNIT B. PAREJIYA, BHAVESH S. BAROT, HETAL K. PATEL, PRAGNA K. SHELAT
Abstract: Sustained release Aceclofenac matrix tablets constituting Kollidon SR (Polyvinyl acetate- povidone based matrix retarding polymer) were developed for manifesting desirable release profile. Matrix tablets were prepared by direct compression of Kollidon SR varying proportion with fixed percentage of aceclofenac. Tablets containing 50 % Kollidon SR demonstrated a rapid rate of drug release with an initial burst effect. Incorporation of more Kollidon SR in the tablet prolonged drug release with subsequent minimization of burst effect as confirmed by mean dissolution time, dissolution efficiency, f2 and drug release kinetic data. The formulation showed close resemblance to commercial product Senafen. The results were explored and explained by the difference of physico-chemical property and micromeritic characteristics. Insignificant effect of various factors e.g. pH, ionic strength, paddle speed was found on drug release. The formulation followed Korsmeyer and peppas kinetic of drug release. Stability study data indicated stable character after short term stability study.
Keyword: Aceclofenac, Kollidon SR, Dissolution efficiency, Senafen, Model fitting
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0.12
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