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Anti-convulsion activity of leaf of Trema orientalis.
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| Author:
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UPLOADED BY-ADMIN, PANCHAL HITEKSHA S., MASTER STAVAN M., SHAH URVASHI D., SALUJA AJAY K., DHOLWANI KISHOR K.
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| Abstract:
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In vitro anti-convulsion activity of Trema orientalis at varying doses of suspension of dried leaves were tested using
Maximum Electroshock induced seizures model and Pentylenetetrazole induced convulsions model. The anti-convulsion
activity of Trema orientalis methanol extract of leaves shows tonic flexion (7.30±1.15 sec) and tonic extension (10.38±1.15
sec) in Maximum Electroshock induced seizures model and onset time (125 sec) in Pentylenetetrazole induced convulsions
model. model which gives more anti-convulsion effect as compared to aqueous extract of leaves which shows tonic flexion
(6.12±1.04 sec) and tonic extension (9.88±1.2 sec) in Maximum Electroshock induced seizures model and onset time (117
sec) in Pentylenetetrazole induced convulsions model of epilepsy but as compared to standard, methanol and aqueous extract
gives less anti-convulsion effect. Phytochemical investigation of Trema orientalis extracts shows presence of tannins
and Phenolic compounds, fixed oils, fats, phytosterols, flavonoids which has been responsible for anti-convulsion activity.
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| Keyword:
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Trema orientalis, Electroshock induced seizures model, Pentylenetetrazole (Metrazol) induced convulsionsmodel, Anti-convulsion activity
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