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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Phytochemical and Pharmacological Properties of Bruguiera gymnorrhiza Roots Extract

Author: UPLOADED BY-ADMIN, M.A RAHMAN, ARIF AHMED, IZ SHAHID
Abstract: Phytochemical analysis of the dried roots of Bruguiera gymnorrhiza (L.) (Family: Rhizophoraceae) indicated the presence of flavonoids, reducing sugars, gums, saponins and tannins. The pharmacological interest of these compounds, coupled with the use of this plant in traditional medicine prompted the authors to check for its possible antinociceptive, antidiarrhea l and GI motility tests in animal models. The extract produced significant writhing inhibition in acetic acid-induced writhing in mice at the oral dose of 250mg/kg and 500 mg/kg body weight (P < 0.001) comparable to the standard drug diclofenac sodium at the dose of 25 mg/kg of body weight. When tested for its antidiarrheal effects on castor oil-induced diarrhea in mice, it increased mean latent period and decreased the frequency of defecation significantly at the dose of 500 mg/kg body weight (P < 0.01), comparable to the standard drug loperamide at the dose of 50 mg/kg of body weight. Moreover, The extract also reduced significantly the charcoal induced Gastro Intestinal (GI) motility in mice; decreased the movement of GI tract in comparison to control animals. The obtained results provide a support for the use of this plant in traditional medicine and its further investigation
Keyword: Phytochemical , Antinociceptive, Antidiarrhea l, GI motility, Bruguiera gymnorhiza, Rhizophoraceae
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